Target Safety
K-Dense-AI/drug-discovery-agent-skillsAssemble the human genetic evidence for and against a target before a programme commits to it — the evidence class that most improves the odds of surviving clinical development. Use this skill to pull gnomAD constraint metrics (LOEUF, pLI, observed/expected) that show whether loss of function is tolerated in people, retrieve GWAS Catalog associations and fine-mapped credible sets for a gene, and read a natural human knockout as a safety readout. Also trigger on gnomAD, LOEUF, pLI, loss-of-function intolerance, mutational constraint, GWAS Catalog, credible set, human knockout, genetic support,...
At a glance
This skill is for Research and helps you assess genetic target safety, retrieve gnomad constraint metrics, and pull gwas catalog associations.
git clone --depth 1 https://github.com/K-Dense-AI/drug-discovery-agent-skills
cp -r drug-discovery-agent-skills/skills/target-safety ~/.claude/skills/target-safety
Geneticsdrug-discoveryGnomadGwasTarget ValidationClinical Development
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