Pkpd Translation
K-Dense-AI/drug-discovery-agent-skillsTurn in vitro potency and animal pharmacokinetics into a defensible human dose projection — the arithmetic that decides whether a compound can reach its target concentration safely. Use this skill for non-compartmental analysis of a concentration-time profile (AUC, Cmax, terminal half-life, clearance, volume of distribution), one- and two-compartment simulation of a dosing regimen, interspecies allometric scaling, human-equivalent dose conversion by body surface area, and the exposure margin between a projected therapeutic concentration and a toxicology no-effect level. Also trigger on non-com...
At a glance
This skill is for Finance and helps you project human doses from animal data, calculate exposure margins for safety, and perform noncompartmental pharmacokinetic analysis.
git clone --depth 1 https://github.com/K-Dense-AI/drug-discovery-agent-skills
cp -r drug-discovery-agent-skills/skills/pkpd-translation ~/.claude/skills/pkpd-translation
PharmacokineticsPkpdDose ProjectionAllometric Scalingdrug-discoveryToxicology
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