Immunogenicity
K-Dense-AI/drug-discovery-agent-skillsEstimate how likely a protein therapeutic is to provoke an anti-drug antibody response, and locate the sequence regions responsible. Use this skill to tile a sequence into peptides, predict class II MHC presentation across a population-representative allele panel, aggregate predicted binders into a per-region and whole-molecule risk score, compare a candidate against its closest human germline, and decide which liabilities are worth deimmunising. Also trigger on immunogenicity, anti-drug antibody, ADA, T-cell epitope, MHC class II, HLA-DRB1, NetMHCIIpan, NetMHCpan, deimmunisation, tregitope, o...
At a glance
This skill is for Presentations and helps you predict protein immunogenicity risk, identify t-cell epitopes in sequences, and estimate anti-drug antibody potential.
git clone --depth 1 https://github.com/K-Dense-AI/drug-discovery-agent-skills
cp -r drug-discovery-agent-skills/skills/immunogenicity ~/.claude/skills/immunogenicity
ImmunogenicityAnti Drug AntibodyMhc PresentationT Cell EpitopeProtein TherapeuticsDeimmunization
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